BVT-948
更新时间：2024-07-17 15:06:30
采购访问：31次
| 常用名 | BVT948 | CAS号 | 39674-97-0 |
|---|---|---|---|
| 价格 | $800.0/100mg $1300.0/250mg $2700.0/1g | 纯度 | 98.0% |
| 备货期 | 3天 | 库存 | 3 |
| 产品网页 | https://www.dcchemicals.com/product_show-DC21685.html | ||
| 产品详情（用途，包装等）
BVT-948 (SPS8I-3) is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) with IC50 of 0.09-1.7 uM. Results show that the effect of BVT948 (BVT.948) is to strengthen the insulin signal and has no effects on the duration of the signal. BVT948 appears to be an effective inhibitor of both protein tyrosine phosphatases (PTP activity and P450 activity)[1]. BVT948 efficiently and selectively suppresses cellular H4 lysine 20 (H4K20me1) at doses lower than 5 μM within 24 h. The cells treated with BVT948 recapitulate cell-cycle-arrest phenotypes similar to what are reported for knocking down SETD8 by RNAi[2]. Treatment of MCF-7 cells with 0.5, 1 or 5 μM of BVT948 for 24 h does not cause any significant changes in cell viability. BVT948 inhibits TPA-induced MMP-9 up-regulation in a dose-dependent manner. Treatment with BVT948 inhibits TPA-stimulated NF-κB binding activity, but not AP-1 binding activity. BVT948 does not affect the MAPK phosphorylation by TPA. Treatment with BVT948 diminishes the TPA-induced cell invasion by 50%[3].Results show that 3 μmol/kg BVT948 (BVT.948) significantly enhances glucose clearance from the blood stream in response to insulin compare with vehicle-treated controls[1]. |
DC Chemicals Limited
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联系人：Tony Cao
联系人电话：13564518121
邮件：sales@dcchemicals.com
网址：http://www.dcchemicals.com
主要市场：
年贸易额：>1000万
外贸占销售比例：
主要合作伙伴：
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：BVT-948
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：BVT 948
- 价格： ￥854.9/10mg ￥2998.9/50mg ￥需询单/1g ￥需询单/1g
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$119/10mM*1mLinDMSO