| 常用名 | NVS-ZP7-4 | CAS号 | 2349367-89-9 |
|---|---|---|---|
| 价格 | $750.0/100mg $750.0/100mg $2500.0/1g | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 3 |
| 产品网页 | https://www.dcchemicals.com/http://www.dcchemicals.com/2349367-89-9.html | ||
| 产品详情(用途,包装等)
NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. NVS-ZP7-4 altered zinc in the ER, and an analog of the compound photoaffinity labeled ZIP7 in cells, suggesting a direct interaction between the compound and ZIP7. NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway. |