NVS-ZP7-4
Published date: 2020-04-10 15:46:05
|
Name | NVS-ZP7-4 | CAS# | 2349367-89-9 |
|---|---|---|---|---|
| Price | $750.0/100mg $750.0/100mg $2500.0/1g | Purity | 98.0% | |
| Stocking Period |
Inquiry | Stock | 3 | |
| Product Webpage: | https://www.dcchemicals.com/http://www.dcchemicals.com/2349367-89-9.html | |||
| Detail
Product Information
NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. NVS-ZP7-4 altered zinc in the ER, and an analog of the compound photoaffinity labeled ZIP7 in cells, suggesting a direct interaction between the compound and ZIP7. NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway. |
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