| 常用名 | JNJ-40418677 | CAS号 | 1146594-87-7 |
|---|---|---|---|
| 价格 | $需询单/100mg $需询单/250mg $需询单/500mg | 纯度 | 98.0% |
| 备货期 | 3天 | 库存 | 3 |
| 产品网页 | https://www.dcchemicals.com/product_show-JNJ-40418677.html | ||
| 产品详情(用途,包装等)
JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting processing of Notch. In human neuroblastoma cells and rat primary neuronal cultures, JNJ-40418677 blocked secretion of Aβb42 (IC50 = 20 nM), with no affects on total Ab concentration, Notch signaling or COX activity. In vivo experiments showed that JNJ-40418677 dose dependently inhibited Aβ42 accumulation in the brain while promoting an increase in Aβ38. |