维达列汀
更新时间：2023-01-18 23:35:31
| 常用名 | 维达列汀 | CAS号 | 274901-16-5 |
|---|---|---|---|
| 价格 | ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 3天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Vildagliptin (LAF-237; NVP-LAF 237) inhibits DPP-4 with IC50 of 2.3 nM.IC50 Value: 2.3 nM[1]Target: DPP-4in vitro: Vildagliptin is an N-substituted glycyl-2-cyanopyrrolidine (figure 2). It is a potent competitive and reversible inhibitor of human and rodent DPP-4 in vitro, with a median inhibitory concentration (IC50) ~2-3 nmol/L. Importantly, vildagliptin inhibits DPP-4 with high specificity relative to other similar peptidases where its IC50 exceeds 200 mol/L [1].in vivo: Compared to age-, gender-, BMI-matched subjects with normal renal function, the mean AUC of vildagliptin after 14 days in patients with mild, moderate, and severe RI increased by 40%, 71%, and 100%, respectively [2]. The treatment was effective in modulating stress in pancreatic tissue, both by reducing levels of stress markers as well as by increasing activity of SOD and catalase. After analyzing the pancreatic histology, we found that vildagliptin was also able to preserve islets and pancreatic β-cells, especially at the concentration of 5 mg/kg [3].Clinical trial: FDA approved drug. 物理化学性质： CAS号：274901-16-5 常用中文名：维达列汀 常用英文名：Vildagliptin (LAF-237) 分子式：C17H25N3O2 分子量：303.39900 密度：1.27 g/cm3 沸点：531.3ºC at 760 mmHg 熔点：153-155?C 闪点：275.1ºC 储存条件：-20°C Freezer |
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：Vildagliptin (LAF-237)
- 价格： ￥373.9/10g ￥30.9/10mg ￥66.9/1g ￥51.9/50mg
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
- 武汉敬康恩生物医药科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：Vildagliptin
- 价格： ￥需询单/100g ￥需询单/500g
- 纯度：98.0%
- 备货期：需询单
- 联系人：周经理
- 盼得（上海）国际贸易有限公司
- 上海市 上海市 徐汇区
- 产品名：维达列汀
- 价格： ￥需询单/500g ￥需询单/1kg ￥需询单/25kg ￥需询单/200kg
- 纯度：0.0%
- 备货期：需询单
- 联系人：叶经理
- 中山星瑞化工有限公司
- 广东省 中山市 中山火炬高技术产业开发区
- 产品名：维达列汀
- 价格： ￥需询单/25kg
- 纯度：99.0%
- 备货期：需询单
- 联系人：王经理
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参考价格：$55/10mM*1mLinDMSO