274901-16-5

• 常用中文名：维达列汀
• 常用英文名：Vildagliptin (LAF-237)
• CAS号：274901-16-5
• 分子式：C₁₇H₂₅N₃O₂
• 分子量：303.39900
• 相关类别： 原料药 循环系统用药 调节血脂药
• 发布时间：2018-04-19 08:00:00
• 更新时间：2026-07-01 19:28:14
• Vildagliptin (LAF-237; NVP-LAF 237)能抑制DPP-4,IC50为2.3 nM。

名称

• 中文名: 维达列汀
• 英文名: Vildagliptin
• 中文别名: VILDAGLIPTIN(专利有效期至2019.12.09); 维格列汀(标准品); 维格列汀杂质SW对照品; 维他列汀; (-)-(2S)-1-[[(3-羟基三环[3.3.1.1[3,7]]硅烷-1-基)氨基]乙酰基]吡咯烷-2-甲腈; 甲醇中维达列汀; 维达列汀S型; 维格列汀 (维达列汀); 维达格列汀; 维达列汀粗品; 维他列汀S型; 维格列汀; (2S)-1-((3-羟基三环[3.3.1.1[3,7]]癸烷-1-基)氨基)乙酰基)吡咯烷-2-腈; 维达列汀母核; 维达利汀; 阿达列汀; 维达列汀/维他列汀/维格列汀; 维格列汀原料药; 维达列汀(维格列汀); 他地那兰; 维格列汀杂质 (VILDAGLIPTIN IMPURITY; 维格列汀,10 MM DMSO 溶液; 维达列汀 (LAF-237); 维格列汀 API; (-)-(2S)-1-[[(3-羟基三环[3.3.1.1[3,7]]癸烷-1-基)氨基]乙酰基]吡咯烷-2-甲腈; 维达列汀Vildagliptin; 维他列汀 , DPP-4抑制剂; 维达列汀VILDAGLIPTIN
• 英文别名: Vildagliptin DPP-4 inhibitor; Vildagliptin -HIS; phma API Vildagliptin; Unii-I6B4B2U96p; Vildagliptin (2S)-1-[2-[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]- 2-pyrrolidinecbonitrile; Vildagliptin //BP; (2S)-1-[2-[(3-hydroxy-1-adamantyl)amino]-acetyl]-pyrrolidin-2-carbonitrile; Vildagliptin (-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile; Galvus; (-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1[3,7]]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile; Vildaliptin; Viggliptin; API Vildagliptin; Top quality API Vildagliptin with best price; (2S)-1-((3-Hydroxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile; Vidaletin; VildagliptinQ: What is Vildagliptin Q: What is the CAS Number of Vildagliptin Q: What is the storage condition of Vildagliptin Q: What e the applications of Vildagliptin; LAF237; GALVUS; NVP-LAF 237; ZOMELIS; Vildagliptin In-House; dagL; (2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]pyrrolidine-2-carbonitrile; Vildagliptin Supplier; Vildagliptin IP/In-House; 1-[2-(3-HydroxyadaMant-1-ylaMino)acetyl]pyrrolidine-2(S)-carbonitrile; Best Quality Vildagliptin with best price CAS NO.274-5; (2S)-1-(2-((3-hydroxyadaMantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile; 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine; Vildagliptin 、VildagliptinAPI; (2S)-1-[N-(3-hydroxytricyclo[3.3.1.1]dec-1-yl)glycyl]pyrrolidine-2-carbonitrile; NVP-LAF; Vildgliptin; (S)-1-[2-[(3-Hydroxyadamant-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile; Vildagliptin 2-Pyrrolidinecbonitrile,1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]; Vildagliptin - Bio-X; Vigliptin; 2-Pyrrolidinecbonitrile, 1-(((3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)amino)acetyl)-, (2S); (-)-(2S)-1-[[(3-Hydroxytricyclo [3.3.1.1[3,7]]dec-1-yl)amino] acetyl]pyrrolidine-2-carbonitrile; 2-Pyrrolidinecbonitrile,1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-, (2S); Vildagliptin, 10 mM in DMSO; VILDAGLIPTIN CAS NO:274-5; Vildagliptin Crude; Vader column dean; DSP7238; (S)-1-[2-(3-Hydroxy-adamantan-1-ylamino)-acetyl]-pyrrolidine-2-carbonitrile; Vidagliptin (see vildagliptin); Laf 237; China Top quality Vildagliptin CAS NO.274-5; ZoMelis; ethyl {2-amino-6-[(4-fluorobenzyl)amino]pyridin-3-yl}cbamate (2Z)-but-2-enedioate; (2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile; Laf; Vildagliptin API; (S)-1-(2-(((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile; (S)-1-[2-((5S,7S)-3-hydroxy-adaMantan-1-ylaMino)-acetyl]-pyrrolidine-2-carbonitrile; Vildagliptin (API) 2-Pyrrolidinecbonitrile,1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]

物化性质

• 密度: 1.27 g/cm3
• 沸点: 531.3ºC at 760 mmHg
• 熔点: 153-155?C
• 分子式: C₁₇H₂₅N₃O₂
• 分子量: 303.39900
• 闪点: 275.1ºC
• 精确质量: 303.19500
• PSA: 76.36000
• LogP: 1.50308
• 外观性状: 白色结晶粉末
• 储存条件: -20°C Freezer

生物活性

• 描述: Vildagliptin (LAF-237; NVP-LAF 237)能抑制DPP-4,IC50为2.3 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 二肽基肽酶
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Villhauer EB, Brinkman JA, Naderi GB et al. 1-[[(3-hydroxy-1-adamantyl) amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem 2003;46:2774-89.

  [2]. He YL, Kulmatycki K, Zhang Y, Pharmacokinetics of vildagliptin in patients with varying degrees of renal impairment. Int J Clin Pharmacol Ther. 2013 Jun 19.

  [3]. Avila Dde L, Araújo GR, Silva M, Vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction in type 1 diabetic rats. Arch Med Res. 2013 Apr;44(3):194-202.

  [4]. Qin CJ, et al. Inhibition of dipeptidyl peptidase IV prevents high fat diet-induced liver cancer angiogenesis by downregulating chemokine ligand 2. Cancer Lett. 2018 Jan 31;420:26-37.

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
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Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%