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Isorhynchophylline

更新时间:2021-07-26 18:31:53 采购访问:20次

常用名 异钩藤碱 CAS号 6859-01-4
价格 $需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg 纯度 98.0%
备货期 需询单 库存 询单
 产品详情(用途,包装等)
用途:
Isorhynchophylline (IRN), an alkaloid isolated from Uncaria rhynchophylla, possesses the effects of lowered blood pressure, vasodilatation and protection against ischemia-induced neuronal damage.IC50 value:Target:In vitro: Isorhynchophylline concentration-dependently inhibited the platelet-derived growth factor (PDGF)-BB-induced proliferation of PASMCs. Fluorescence-activated cell-sorting analysis showed that isorhynchophylline caused G0/G1 phase cell cycle arrest [2]. Isorhynchophylline can significantly attenuate the cardiomyocyte hypertrophy induced by AngⅡ [3].In vivo: Isorhynchophylline significantly improved spatial learning and memory function in the D-gal-treated mice. Isorhynchophylline significantly increased the level of glutathione (GSH) and the activities of superoxide dismutase (SOD) and catalase (CAT), while decreased the level of malondialdehyde (MDA) in the brain tissues of the D-gal-treated mice [1]. Isorhynchophylline prevented monocrotaline induced pulmonary arterial hypertension in rats, as assessed by right ventricular (RV) pressure, the weight ratio of RV to (left ventricular+septum) and RV hypertrophy. Isorhynchophylline significantly attenuated the percentage of fully muscularized small arterioles, the medial wall thickness, and the expression of smooth muscle α-actin (α-SMA) and proliferating cell nuclear antigen (PCNA) [2].
物理化学性质:
CAS号:6859-01-4
常用中文名:异钩藤碱
常用英文名:Isorhyncophylline
分子式:C22H28N2O4
分子量:384.47
密度:1.4±0.1 g/cm3
沸点:447.6±25.0 °C at 760 mmHg
熔点:114ºC
闪点:224.5±23.2 °C
储存条件:室温

供应商信息

达阳化工(杭州)有限公司 认证供应商

认证状态:已认证供应商
商品数:50181件
电话:+86571-88938639
地址:浙江省杭州市西湖区文三路259号2栋9楼
地区: 浙江省 杭州市 西湖区
联系人:王小姐
联系人电话:+86-571-8893-8639
邮件:enquiry@dycnchem.com
网址:http://www.dycnchem.com
主要市场:Mainly in Southeast Asia and European and American markets
年贸易额:10 to 20 million USD
外贸占销售比例:90%
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参考价格:$191/10mM*1mLinDMSO
其他供应商价格:
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