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6859-01-4生产厂家

6859-01-4价格

6859-01-4

6859-01-4结构式
6859-01-4结构式
  • 常用中文名:异钩藤碱
  • 常用英文名:Isorhyncophylline
  • CAS号:6859-01-4
  • 分子式:C22H28N2O4
  • 分子量:384.47
  • 相关类别: 天然产物 生物碱
  • 发布时间:2018-09-06 06:22:22
  • 更新时间:2024-01-02 20:17:51
  • 异钩藤碱 (Isorhynchophylline) 是从钩藤中分离得到的生物碱类化合物,能够降血压、舒张血管、保护神经免于局部缺血造成损伤。

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中文名 异钩藤碱
英文名 isorhynchophylline
英文别名 7-Isorhynchophylline
5-Methoxyindole-3-carboxylic Acid Hydrate
7-Isorhyncophylline
5-Methoxyindole-3-Carboxylic Acid
(16E,20α)-17-Methoxy-2-oxocorynox-16-en-16-carboxylic acid
Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, (αE,3S,6'R,7'S,8'aS)-
Isorhyncophylline
5-methoxyindole-2-carboxylic acid
1H-Indole-3-carboxylic acid, 5-methoxy-
5-Methoxy-1H-indole-3-carboxylic acid
密度 1.4±0.1 g/cm3
沸点 447.6±25.0 °C at 760 mmHg
熔点 114ºC
分子式 C22H28N2O4
分子量 384.47
闪点 224.5±23.2 °C
PSA 78.87000
LogP 1.90
蒸汽压 0.0±1.1 mmHg at 25°C
折射率 1.677
储存条件 室温

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GN1605000
CHEMICAL NAME :
Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (16E,20-alpha)-
CAS REGISTRY NUMBER :
6859-01-4
LAST UPDATED :
198909
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C22-H28-N2-O4
MOLECULAR WEIGHT :
384.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
217 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,17,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,17,1989

安全声明 (欧洲) 24/25