1-(2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL)-5-(TRIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-2(3H)-ONE
更新时间：2022-01-28 17:32:46
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| 常用名 | 1-(2-羟基-5-(三氟甲基)苯基)-5-(三氟甲基)-1H-苯并[d]咪唑-2(3h)-酮 | CAS号 | 153587-01-0 |
|---|---|---|---|
| 价格 | $需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： NS-1619 is a selective large conductance Ca2+-activated K+-channel activator.IC50 value: Target: Ca2+-activated K+-channel activatorNS 1619 (3-100 microM) produced a concentration-dependent inhibition of spontaneous activity in rat portal vein characterized by a reduction in the amplitude and duration of the tension waves. This inhibition was slightly potentiated in the presence of either charybdotoxin (250 nM) or penitrem A (1 microM) [1]. NS-1619 induced concentration-dependent activation of BKCa channels with a calculated EC50 of 32 microM. The NS 1619-induced activity was dependent on the presence of free Ca2+ at the intracellular surface, but was not associated with a change in channel voltage sensitivity [2]. NS 1619 (50 microM) inhibited the noradrenaline-induced contraction. NS 1619 (10-100 microM) reduced the high K+-induced contractions in a noncompetitive manner [3]. Inhalation of a 12 μM and 100 μM NS1619 solution significantly reduced RV pressure without affecting systemic arterial pressure. Blood gas analyses demonstrated significantly reduced carbon dioxide and improved oxygenation in NS1619-treated animals pointing towards a considerable pulmonary shunt-reducing effect. In PASMC's, NS1619 (100 μM) significantly attenuated PASMC proliferation by a pathway independent of AKT and ERK1/2 activation [4]. 物理化学性质： CAS号：153587-01-0 常用中文名：1-(2-羟基-5-(三氟甲基)苯基)-5-(三氟甲基)-1H-苯并[d]咪唑-2(3h)-酮 常用英文名：NS-1619 分子式：C15H8F6N2O2 分子量：362.22700 密度：1.563g/cm3 沸点：N/A 熔点：234 °C(dec.) 闪点：N/A 储存条件：存放于惰性气体之中;避免空气 |
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主要合作伙伴：
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：NS-1619
- 价格： ￥294.9/25mg ￥119.9/5mg ￥940.9/100mg ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
2881459338
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- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：1-(2-羟基-5-(三氟甲基)苯基)-5-(三氟甲基)-1H苯并[d]咪唑-2(3H)-酮
- 价格： ￥需询单/100mg ￥需询单/10mg ￥需询单/1g ￥需询单/250mg
- 纯度：98.0%
- 备货期：需询单
- 联系人：王汐瑶
3623107365
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- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：1-(2-羟基-5-(三氟甲基)苯基)-5-(三氟甲基)-1H苯并[d]咪唑-2(3H)-酮
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
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1-(2-羟基-5-(三氟甲基)苯基)-5-(三氟甲基)-1H-苯并[d]咪唑-2(3h)-酮生产厂家
参考价格：￥560/5mg