ANDROGRAPHOLIDE, DEOXY-
更新时间：2022-02-12 12:04:29
采购访问：25次
| 常用名 | 去氧穿心莲内酯 | CAS号 | 79233-15-1 |
|---|---|---|---|
| 价格 | $需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Deoxyandrographolide is a natural compound extracted from A. paniculata; potently inhibit the growth of liver (HepG2 and SK-Hep1) and bile duct (HuCCA-1 and RMCCA-1) cancer cells.IC50 value:Target: Anticancer natural compoundin vitro: Treatment with 14-DAG activated AMPK through induction of cyclic AMP-protein kinase A pathway. 14-DAG controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. In conclusion, our results indicated that 14-DAG was capable of preventing the development of fatty liver through AMPK-mediated regulation of lipid metabolism [1]. 14-DAG down-regulated the formation of death-inducing signalling complex, resulting in desensitization of hepatocytes to TNF-alpha-induced apoptosis. Pretreatment of hepatocytes with 14-DAG accentuated microsomal Ca-ATPase activity through induction of NO/cGMP pathway [2]. 14-DAP, in concentrations between 10-100 microM, reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner. In addition, 14-DAP reduced PAF-induced calcium flux in the presence of extracellular calcium, and tyrosine phosphorylation of a 44 kDa protein corresponding to the MAPK(ERK1) [3]. in vivo: Half of the ethanol-fed animals received 14-deoxyandrographolide (14-DAG) treatment for the last 4 weeks of study. protective effect of 14-DAG against ethanol-induced hepatic injury is based on its ability to reduce oxidative stress through cNOS dependent improvement of redox status. 14-DAG mediated activation of adenylate cyclase-cAMP signaling leading to up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism [4]. 物理化学性质： CAS号：79233-15-1 常用中文名：去氧穿心莲内酯 常用英文名：Deoxyandrographolide 分子式：C20H30O4 分子量：334.450 密度：1.1±0.1 g/cm3 沸点：511.7±50.0 °C at 760 mmHg 熔点：N/A 闪点：178.2±23.6 °C 储存条件：2-8℃ |
达阳化工（杭州）有限公司
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地址：浙江省杭州市西湖区文三路259号2栋9楼
地区： 浙江省 杭州市 西湖区
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主要市场：Mainly in Southeast Asia and European and American markets
年贸易额：10 to 20 million USD
外贸占销售比例：90%
主要合作伙伴：
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：去氧穿心莲内酯
- 价格： ￥3438.0/5mg
- 纯度：98.0%
- 备货期：2天
- 联系人：刘佳
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：去氧穿心莲内酯
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 四川恒诚致远生物科技有限公司
- 四川省 成都市 温江区
- 产品名：去氧穿心莲内酯
- 价格： ￥需询单/5mg ￥需询单/20mg ￥需询单/100mg ￥需询单/1g
- 纯度：98.0%
- 备货期：需询单
- 联系人：张半夏
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参考价格：$420/5mg