STING agonist-1
更新时间：2023-02-23 17:36:08
采购访问：26次
| 常用名 | STING激动剂-1 | CAS号 | 702662-50-8 |
|---|---|---|---|
| 价格 | $需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： STING agonist-1 (G10) is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) (IC90 = 24.57 μM). IC50 value: 24.57 μM (IC90)Target: VEEV, STINGin vitro: G10 does not bind to STING directly, however, G10 represents the first synthetic small molecule characterized as an indirect activator of human STING-dependent phenotypes.100 μM G10 (a concentration over twelve times the IC90 for CHIKV and over four times the IC90 for VEEV). G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts. G10 Induces IFN/IRF3- but not NF-κB-Dependent Transcription in Human Fibroblasts. G10 activates IRF3, but not canonical NF-κB pathways in human fibroblasts. G10 elicits antiviral activity against New and Old World Alphaviruses. G10 stimulates phosphorylation of IFN regulatory factor 3 (IRF3) in a manner similar to that triggered by UV-inactivated cytomegalovirus (UV-CMV) and Sendai virus (SeV). G10 induces synthesis and secretion of bioactive type I and III IFNs and generates an antiviral state in fibroblast cells positive for STING, IRF3, and STAT1 proteins. G10 triggers innate immune responses that involve expression of IRF3-dependent genes including type I and III interferons. 物理化学性质： CAS号：702662-50-8 常用中文名：STING激动剂-1 常用英文名：G10, STING signaling activator 分子式：C21H16ClFN2O3S 分子量：430.880 密度：1.4±0.1 g/cm3 沸点：668.3±55.0 °C at 760 mmHg 熔点：N/A 闪点：358.0±31.5 °C 储存条件：2-8℃ |
达阳化工（杭州）有限公司
认证状态：已认证供应商
商品数：48306件
电话：+86571-88938639
地址：浙江省杭州市西湖区文三路259号2栋9楼
地区： 浙江省 杭州市 西湖区
联系人：王小姐
联系人电话：+86-571-8893-8639
邮件：enquiry@dycnchem.com
网址：http://www.dycnchem.com
主要市场：Mainly in Southeast Asia and European and American markets
年贸易额：10 to 20 million USD
外贸占销售比例：90%
主要合作伙伴：
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：G10, STING signaling activator
- 价格： ￥308.9/1mg ￥8136.9/100mg ￥1586.9/10mg ￥2523.9/25mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
2881459338
复制
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：STINGagonist-1
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
351666998
复制
13311869306
复制
查看所有供应商和价格请点击：
参考价格：$462/10mM*1mLinDMSO