盐酸依非地平
更新时间：2025-08-21 15:14:29
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| 常用名 | 依福地平盐酸盐 | CAS号 | 111011-53-1 |
|---|---|---|---|
| 价格 | ￥2708.0/50mg ￥需询单/1g ￥需询单/1g ￥需询单/1g | 纯度 | 98.0% |
| 备货期 | 1天 | 库存 | 现货 |
| 产品网页 | http://www.aladdin-e.com/zh_cn/E336292.html | ||
| 产品详情（用途，包装等）
用途： Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).IC50 value: Target: calcium channel blockerin vitro: Efonidipine and nifedipine, but not other examined CCBs, also increased the N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP)-induced StAR mRNA, which reflects the action of adrenocorticotropic hormone, and efonidipine and R(-)-efonidipine enhanced the dbcAMP-induced DHEA-S production in NCI-H295R adrenocortical carcinoma cells [1]. I(Ca(T)) was blocked mainly by a tonic manner by nifedipine, by a use-dependent manner by mibefradil, and by a combination of both manners by efonidipine. IC50s of these Ca2+ channel antagonists to I(Ca(T)) and L-type Ca2+ channel current (I(Ca(L))) were 1.2 micromol/l and 0.14 nmol/l for nifedipine; 0.87 and 1.4 micromol/l for mibefradil, and 0.35 micromol/l and 1.8 nmol/l for efonidipine, respectively [4].in vivo: Twenty hypertensive patients on chronic hemodialysis were given efonidipine 20-60 mg twice daily and amlodipine 2.5-7.5 mg once daily for 12 weeks each in a random crossover manner. The average blood pressure was comparable between the efonidipine and amlodipine periods (151 + or - 15/77 + or - 8 versus 153 + or - 15/76 + or - 8 mmHg). The pulse rate did not change significantly during the administration periods [2]. In the UM-X7.1 group, EFO treatment significantly attenuated the decrease of LVEF without affecting blood pressure compared with the vehicle group. EFO treatment decreased heart rate (by approximately 10%) in both groups [3]. 物理化学性质： CAS号：111011-53-1 常用中文名：依福地平盐酸盐 常用英文名：Efonidipine (hydrochloride) 分子式：C34H39ClN3O7P 分子量：668.11600 密度：N/A 沸点：746.9ºC at 760 mmHg 熔点：169-170ºC 闪点：405.5ºC 储存条件：2-8℃ |
上海阿拉丁生化科技股份有限公司
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- 产品名：盐酸依非地平
- 价格： ￥2708.0/50mg ￥需询单/1g ￥需询单/1g ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$96/10mg