产品详情(用途,包装等)
NAV 2729 (NAV2729) is a novel, direct and selective small molecule inhibitor of small GTPase ARF6 with IC50 of 1.5 uM in nucleotide exchange assays; shows no inhibitory effects for all other human ARF family members, as well as other small GTPases, such as RhoA, Rac1, H-Ras, and Cdc42 (IC50>50 uM); inhibits all known signaling pathways downstream of oncogenic GNAQ in uveal melanoma cells, including PLC/PKC, Rho/Rac, YAP, and β-catenin; reduces uveal melanoma cell proliferation and tumorigenesis in mouse models.
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