常用名 | 链霉素 | CAS号 | 120191-51-7 |
---|---|---|---|
价格 | ¥需询单/1g | 纯度 | 98.9% |
备货期 | 1天 | 库存 | 现货 |
产品详情(用途,包装等)
Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs). Streptochlorin prevents degranulation in antigen-stimulated mast cells, as well as inhibits Syk kinase and the Src family kinases LYN and Fyn and reduces the secretion of TNF-α and IL-4 induced by dinitrophenyl-human serum album (DNP-HSA) in RBL-2H3 mast cells. It also decreases swelling and reduces scratching behavior in a mouse model of allergic dermatitis induced by dinitrofluorobenzene (DNFB). |