WS3
更新时间：2025-08-28 01:09:18
采购访问：60次
| 常用名 | N-[6-[4-[[[[4-[(4-甲基-1-哌嗪基)甲基]-3-(三氟甲基)苯基]氨基]羰基]氨基]苯氧基]-4-嘧啶基]环丙烷甲酰胺 | CAS号 | 1421227-52-2 |
|---|---|---|---|
| 价格 | ￥需询单/1g ￥需询单/5g | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： WS3 is a novel small molecule that promotes β cell proliferation with EC50 of 28 nM(induced R7T1 proliferation).EC50 value: 28 nM [1]Target: β cell proliferation agonistProtocol(Only for Reference) [1]In vivo efficacy studies in RIP-DTA mice:RIP-DTA mice were purchased from Jackson Laboratories and all aspects of their treatment were outlined in a protocol approved by an internal animal care and use committee (IACUC). Mice were housed as 3-5 mice per cage and fed standard chow and water. During disease induction, doxycycline was added to the drinking water at a concentration of 2 mg/mL. Animals were injected intraperitoneally with saline-formulated WS6 at 5 mg/kg once every other day (for efficacy study). Blood glucose was monitored every third day. Mice were sacrificed at the end of week 1 and pancreas was fixed in formalin, sectioned, and stained for Ki67 and insulin. At the end of week 6, wet pancreas weight was recorded, and fixed pancreata were sectioned and stained for insulin; total insulin area and wet weight were used to calculate beta cell mass. For pharmacokinetic studies, WS6 was formulated at 50 mg/kg and given as single intraperitoneal dose, followed by serum collection and analysis of compound concentration in serum to determine CMAX and half-life (T1/2). 物理化学性质： CAS号：1421227-52-2 常用中文名：N-[6-[4-[[[[4-[(4-甲基-1-哌嗪基)甲基]-3-(三氟甲基)苯基]氨基]羰基]氨基]苯氧基]-4-嘧啶基]环丙烷甲酰胺 常用英文名：WS3 分子式：C28H30F3N7O3 分子量：569.578 密度：1.4±0.1 g/cm3 沸点：632.9±55.0 °C at 760 mmHg 熔点：N/A 闪点：336.6±31.5 °C 储存条件：2-8°C |
武汉敬康恩生物医药科技有限公司
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地区： 湖北省 武汉市 东西湖区
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联系人电话：15871494362
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- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：WS3
- 价格： ￥283.9/10mg ￥452.9/25mg ￥723.9/50mg ￥171.9/5mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 武汉敬康恩生物医药科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：WS3
- 价格： ￥需询单/1g ￥需询单/5g
- 纯度：98.0%
- 备货期：需询单
- 联系人：周经理
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N-[6-[4-[[[[4-[(4-甲基-1-哌嗪基)甲基]-3-(三氟甲基)苯基]氨基]羰基]氨基]苯氧基]-4-嘧啶基]环丙烷甲酰胺生产厂家
参考价格：$99/10mM*1mLinDMSO