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CC-122

更新时间:2025-08-28 18:54:19

常用名 CC122 CAS号 1015474-32-4
价格 ¥需询单/1g ¥需询单/5g 纯度 98.0%
备货期 需询单 库存 现货
 产品详情(用途,包装等)
用途:
CC-122 is a novel agent for DLBCL with antitumor and immunomodulatory activity.CC-122 binds CRBN and degrades Aiolos and Ikaros resulting in a mimicry of IFN signaling and apoptosis in DLBCL.In vitro: CC122 inhibits proliferation and induces apoptosis in ABC and GCB DLBCL. In DLBCL cell lines, CC122-induced degradation or short hairpin RNA-mediated knockdown of Aiolos and Ikaros correlates with increased transcription of interferon (IFN)-stimulated genes independent of IFN-α, -β, and -γ production and/or secretion and results in apoptosis in both activated B-cell (ABC) and germinal center B-cell DLBCL.[1]In vivo: Treatment of female CB-17 SCID mice with CC122 at 3 or 30 mg/kg once daily significantly decreased tumor growth in OCI-LY10 ABC-DLBCL (P = .028 and P 物理化学性质:
CAS号:1015474-32-4
常用中文名:CC122
常用英文名:CC122
分子式:C14H14N4O3
分子量:286.28600
密度:N/A
沸点:N/A
熔点:N/A
闪点:N/A
储存条件:-20℃

供应商信息

武汉敬康恩生物医药科技有限公司

认证状态:未认证供应商
电话:15871494362
地址:光谷大道58号
地区: 湖北省 武汉市 东西湖区
联系人:周经理
联系人电话:15871494362
邮件:orders@jknbiochem.com
网址:http://www.jknbiochem.com
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参考价格:$189/10mM*1mLinDMSO
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查看所有价格,请点击CC122价格