CC122

• 常用名: CC122
• 英文名: CC122
• CAS号: 1015474-32-4
• 分子量: 286.28600
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₄N₄O₃
• 熔点: N/A
• 闪点: N/A

CC122用途

CC122是一种新型的治疗DLBCL的药物,具有抗肿瘤和调节免疫活动的作用。CC122可以结合CRBN,通过降解Aiolos和Ikaros可以模仿干扰素信号,引发DLBCL的细胞凋亡。

CC122名称

• 中文名: CC122
• 英文名: cc-122

CC122生物活性

• 描述: CC122是一种新型的治疗DLBCL的药物,具有抗肿瘤和调节免疫活动的作用。CC122可以结合CRBN,通过降解Aiolos和Ikaros可以模仿干扰素信号,引发DLBCL的细胞凋亡。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> E1/E2/E3酶
  研究领域 >> 癌症
• 参考文献:

  [1]. Hagner, P.R.et al.CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL.Blood.Aug 6;126(6):779-89.

CC122物理化学性质

• 分子式: C₁₄H₁₄N₄O₃
• 分子量: 286.28600
• 精确质量: 286.10700
• PSA: 107.08000
• LogP: 1.17480
• InChIKey: RSNPAKAFCAAMBH-UHFFFAOYSA-N
• SMILES: Cc1nc2cccc(N)c2c(=O)n1C1CCC(=O)NC1=O
• 外观性状: 粉末
• 储存条件: -20℃

CC122靶点实验

查看更多实验

实验名称：Bioavailability in ICR mouse at 10 mg/kg, po measured for 24 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5356165

实验名称：Volume of distribution at steady state in ICR mouse at 1 mg/kg, iv measured for 24 hr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5356163

实验名称：Clearance in ICR mouse at 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5356164

实验名称：Half life in ICR mouse at 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5356159

实验名称：Half life in ICR mouse at 10 mg/kg, po measured for 24 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5356160

实验名称：MRT (0 to infinity) in ICR mouse at 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5356157

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-SW13-72hr

实验名称：MRT (0 to infinity) in ICR mouse at 10 mg/kg, po measured for 24 hrs by LC-MS/MS anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5356158

实验名称：AUC (0 to infinity) in ICR mouse at 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5356155

实验名称：AUC (0 to infinity) in ICR mouse at 10 mg/kg, po measured for 24 hrs by LC-MS/MS anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5356156

共41条，当前第1页，共5页

1

2

3

4

5

CC122英文别名

• 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)piperidine-2,6-dione
• 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione
• rac-3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione
• 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)-piperidin-2,6-dione
• 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione
• CC122