AZD3514
更新时间：2023-08-31 11:12:10
| 常用名 | AZD3514 | CAS号 | 1240299-33-5 |
|---|---|---|---|
| 价格 | ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.IC50 Value: 2.2 uM (Ki)Target: androgen receptorAZD3514 binds to the AR ligand binding domain and has selectivity for binding to AR over other nuclear hormone receptors [1]. in vitro: AZD3514 inhibits cell growth in prostate cancer cells expressing wild-type (VCaP) and mutated (T877A) AR (LNCaP), but is inactive in AR-negative prostate cancer cells, indicating a dependency on AR for efficacy [2]. in vivo: We assessed activity initially in the Hershberger castrated rat assay in which oral dosing of AZD3514 (100mg/kg once-daily for 7 days) significantly inhibited testosterone-induced growth of sexual accessory organs [2]. Clinical trial: Open-label Prostate Cancer Study. Phase 1 物理化学性质： CAS号：1240299-33-5 常用中文名：AZD3514 常用英文名：AZD3514 分子式：C25H32F3N7O2 分子量：519.563 密度：1.4±0.1 g/cm3 沸点：669.5±65.0 °C at 760 mmHg 熔点：N/A 闪点：358.7±34.3 °C 储存条件：-20℃ |
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：AZD3514
- 价格： ￥617.9/5mg ￥5149.9/100mg ￥2059.9/25mg ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：AZD3514
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
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参考价格：$110/10mM*1mLinDMSO