AZD3514

• 常用名: AZD3514
• 英文名: AZD3514
• CAS号: 1240299-33-5
• 分子量: 519.563
• 密度: 1.4±0.1 g/cm3
• 沸点: 669.5±65.0 °C at 760 mmHg
• 分子式: C₂₅H₃₂F₃N₇O₂
• 熔点: N/A
• 闪点: 358.7±34.3 °C

AZD3514用途

AZD3514是口服的雄激素受体负调节剂,Ki为2.2 μM,可降低AR蛋白的表达。

AZD3514名称

• 中文名: AZD3514
• 英文名: 1-[4-[2-[4-[1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]ethyl]piperazin-1-yl]ethanone

AZD3514生物活性

• 描述: AZD3514是口服的雄激素受体负调节剂,Ki为2.2 μM,可降低AR蛋白的表达。
• 相关类别:
  信号通路 >> 其他 >> 雄激素受体
  研究领域 >> 癌症
• 参考文献:

  [1]. Bradbury RH, et al. Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1945-8.

  [2]. Sarah A Loddick, Rob Bradbury, Nicola Broadbent. Abstract 3848: Preclinical profile of AZD3514: A small molecule-targeting androgen receptor function with a novel mechanism of action and the potential to treat castration-resistant prostate cancer. Cancer

AZD3514物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 669.5±65.0 °C at 760 mmHg
• 分子式: C₂₅H₃₂F₃N₇O₂
• 分子量: 519.563
• 闪点: 358.7±34.3 °C
• 精确质量: 519.256958
• PSA: 79.09000
• LogP: 1.16
• InChIKey: JMEYDSHPKCSIJC-UHFFFAOYSA-N
• SMILES: CC(=O)N1CCN(CCOc2ccc(C3CCN(C4=Nn5c(nnc5C(F)(F)F)CC4)CC3)cc2)CC1
• 外观性状: 粉末
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.642
• 储存条件: -20℃

AZD3514靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Confirmatory qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS2-PP-HEK293ACE2-f4-mipe-npc

实验名称：VSVG counterscreen qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-VSVG-PP-HEK293ACE2-f4-mipe-npc

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

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AZD3514英文别名

• S7040,AZD 3514
• 6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine
• 1-(4-(2-(4-(1-(3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)piperazin-1-yl)ethanone
• 1-{4-[2-(4-{1-[3-(Trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-piperidinyl}phenoxy)ethyl]-1-piperazinyl}ethanone
• AZD3514