ONX0914
更新时间：2025-09-05 20:00:17
| 常用名 | ONX-0914 | CAS号 | 960374-59-8 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： ONX-0914 (PR-957) is a potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome.IC50 Value: ~10 nM [1]in vitro: PR-957 blocked presentation of LMP7-specific, MHC-I-restricted antigens in vitro and in vivo. Selective inhibition of LMP7 by PR-957 blocked production of interleukin-23 (IL-23) by activated monocytes and interferon-gamma and IL-2 by T cells [1].in vivo: In mouse models of rheumatoid arthritis and lupus, ONX-0914 treatment reverses signs of disease and results in reductions in cellular infiltration, cytokine production and autoantibody levels at well-tolerated doses. The maximum tolerated dose (MTD) of ONX-0914 in mice to be 30 mg/kg body weight. IFN-g release is inhibited by ~60% at LMP7-selective concentrations of ONX-0914 and by ~90% at higher concentrations. Production of IL-2 is also inhibited by ~50% [1]. 物理化学性质： CAS号：960374-59-8 常用中文名：ONX-0914 常用英文名：ONX-0914 (PR-957) 分子式：C31H40N4O7 分子量：580.672 密度：1.2±0.1 g/cm3 沸点：878.0±65.0 °C at 760 mmHg 熔点：N/A 闪点：484.8±34.3 °C 储存条件：2-8°C |
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：ONX-0914 (PR-957)
- 价格： ￥1441.9/10mg ￥2574.9/25mg ￥782.9/5mg ￥5973.9/100mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$77/10mM*1mLinDMSO