ONX-0914

• 常用名: ONX-0914
• 英文名: ONX-0914 (PR-957)
• CAS号: 960374-59-8
• 分子量: 580.672
• 密度: 1.2±0.1 g/cm3
• 沸点: 878.0±65.0 °C at 760 mmHg
• 分子式: C₃₁H₄₀N₄O₇
• 熔点: N/A
• 闪点: 484.8±34.3 °C

ONX-0914用途

ONX-0914 (PR-957)是免疫蛋白酶体抑制剂,与其它蛋白酶体的交叉反应极小。

ONX-0914名称

• 中文名: ONX-0914
• 英文名: (2S)-3-(4-methoxyphenyl)-N-[(2S)-1-(2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide

ONX-0914生物活性

• 描述: ONX-0914 (PR-957)是免疫蛋白酶体抑制剂,与其它蛋白酶体的交叉反应极小。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 蛋白酶体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Muchamuel T, et al. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nat Med. 2009 Jul;15(7):781-7.

ONX-0914物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 878.0±65.0 °C at 760 mmHg
• 分子式: C₃₁H₄₀N₄O₇
• 分子量: 580.672
• 闪点: 484.8±34.3 °C
• 精确质量: 580.289673
• PSA: 149.07000
• LogP: 3.41
• InChIKey: WQAVPPWWLLVGFK-UHFFFAOYSA-N
• SMILES: COc1ccc(CC(NC(=O)C(C)NC(=O)CN2CCOCC2)C(=O)NC(Cc2ccccc2)C(=O)C2(C)CO2)cc1
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.569
• 储存条件: 2-8°C

ONX-0914靶点实验

查看更多实验

实验名称：Antifibrotic activity in human THP-1 cells assessed as reduction in LPS stimulated TI... 来源：ChEMBL 靶标：THP-1 External Id：CHEMBL5636958

实验名称：Irreversible inhibition of 20S immuno proteosome beta5i subunit in human MOLT-4 cells... 来源：ChEMBL 靶标：Proteasome subunit beta type-8 External Id：CHEMBL5636959

实验名称：Inhibition of human 20S immuno proteosome beta5i subunit using Ac-ANW-AMC as substrat... 来源：ChEMBL 靶标：Proteasome subunit beta type-8 External Id：CHEMBL5636945

实验名称：Inhibition of human 20S immuno proteosome beta5i subunit using Ac-ANW-AMC as substrat... 来源：ChEMBL 靶标：Proteasome subunit beta type-8 External Id：CHEMBL5636946

实验名称：Inhibition of chymotrypsin-like activity of human constitutive 20S proteasome beta 5 ... 来源：ChEMBL 靶标：Proteasome subunit beta type-5 External Id：CHEMBL2343625

实验名称：Inhibition of human 20S immuno proteosome beta5c subunit using Ac-WLA-AMC as substrat... 来源：ChEMBL 靶标：Proteasome subunit beta type-5 External Id：CHEMBL5636947

实验名称：Inhibition of chymotrypsin-like activity of human 20S immunoproteasome beta 5 subunit... 来源：ChEMBL 靶标：Proteasome subunit beta type-8 External Id：CHEMBL2343623

实验名称：Inhibition of immunoproteasome caspase-like activity in human erythrocytes using Z-LR... 来源：ChEMBL 靶标：Proteasome subunit beta type-1 External Id：CHEMBL4186915

实验名称：Inhibition of immunoproteasome trypsin-like activity in human erythrocytes using Z-nL... 来源：ChEMBL 靶标：Proteasome subunit beta type-2 External Id：CHEMBL4186916

实验名称：Inhibition of 20s constitutive proteasome chymotrypsin-like activity in human erythro... 来源：ChEMBL 靶标：Proteasome subunit beta type-5 External Id：CHEMBL4186911

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ONX-0914英文别名

• qc-7242
• 4,5-Anhydro-1,2-dideoxy-4-methyl-2-{[N-(4-morpholinylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-erythro-pent-3-ulose
• ONX-0914
• ONX0914