6,7-二甲氧基-4-[(5-甲基-1,3,4-噻二唑-2-基)硫基]喹唑啉

更新时间：2025-08-27 16:53:56

6,7-二甲氧基-4-[(5-甲基-1,3,4-噻二唑-2-基)硫基]喹唑啉结构式	常用名	6,7-二甲氧基-4-[(5-甲基-1,3,4-噻二唑-2-基)硫基]喹唑啉	英文名	SKLB1002
	CAS号	1225451-84-2	分子量	320.390
	密度	1.5±0.1 g/cm3	沸点	522.4±60.0 °C at 760 mmHg
	分子式	C₁₃H₁₂N₄O₂S₂	熔点	193 °C
	MSDS	中文版美版	闪点	269.7±32.9 °C
	符号	GHS06	信号词	Danger

用途

SKLB1002 is a novel and potent VEGFR-2 inhibitor with an IC50 value of 32 nM.

中文名	6,7-二甲氧基-4-[(5-甲基-1,3,4-噻二唑-2-基)硫基]喹唑啉
英文名	2-(6,7-dimethoxyquinazolin-4-yl)sulfanyl-5-methyl-1,3,4-thiadiazole
英文别名	更多

密度	1.5±0.1 g/cm3
沸点	522.4±60.0 °C at 760 mmHg
熔点	193 °C
分子式	C₁₃H₁₂N₄O₂S₂
分子量	320.390
闪点	269.7±32.9 °C
精确质量	320.040161
PSA	123.56000
LogP	2.40
InChIKey	RQVGFDBMONQTBC-UHFFFAOYSA-N
SMILES	COc1cc2ncnc(Sc3nnc(C)s3)c2cc1OC
外观性状	固体;White to Light yellow powder to crystal
蒸汽压	0.0±1.3 mmHg at 25°C
折射率	1.687
储存条件	<0°C

符号	GHS06
信号词	Danger
危害声明	H301
警示性声明	P301 + P310 + P330
危害码 (欧洲)	T+
危险品运输编码	UN 2811 6.1 / PGIII

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
来源：ChEMBL
靶标：Replicase polyprotein 1ab
External Id：CHEMBL4495582

实验名称：Antiangiogenic activity in zebrafish embryos assessed as inhibition of intersegmental...
来源：ChEMBL
靶标：Danio rerio
External Id：CHEMBL2186454

实验名称：Antiangiogenic activity in HUVEC assessed as inhibition of tube formation at 10 uM
来源：ChEMBL
靶标：HUVEC
External Id：CHEMBL2186455

实验名称：Antitumor activity against human SW620 cells xenografted mouse assessed as inhibition...
来源：ChEMBL
靶标：SW-620
External Id：CHEMBL2186453

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate
来源：ChEMBL
靶标：Histone deacetylase 6
External Id：CHEMBL4808149

实验名称：Antitumor activity against human HepG2 cells xenografted mouse assessed as inhibition...
来源：ChEMBL
靶标：HepG2
External Id：CHEMBL2185929

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate
来源：ChEMBL
靶标：Histone deacetylase 6
External Id：CHEMBL4808150

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV)
来源：NCGC
External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase...
来源：NCGC
External Id：GPx1-biochemical-p4-p7

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：HCMV UL50
External Id：HMS1262

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SKLB1002-25mg

6,7-Dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]quinazoline

SKLB1002

S7258

SKLB1002-10mg

SKLB1002-5mg

SKLB1002-50mg