WEHI345
更新时间：2024-09-01 18:19:31
| 常用名 | WEHI-345 | CAS号 | 1354825-58-3 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM.IC50 value: 0.13 μMTarget: RIPK2in vitro: WEHI-345 is a selective RIPK2 kinase inhibitor, which delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement. WEHI-345 is an ATP analogue and was therefore predicted to bind in the ATP-binding pocket of RIPK2. WEHI-345 proved to be highly specific for RIPK2(Kd=46 nM) and displayed negligible activity (>10 μM) against RIPK1, RIPK4 and RIPK5.in vivo: WEHI-345 inhibits NOD signalling and has a beneficial effect on an EAE model. WEHI-345 blocks MDP-induced cytokine production. WEHI-345 ameliorates experimental autoimmune encephalomyelitis in mice. WEHI-345 also potently inhibited MDP-induced cytokine and chemokine secretion in the mouse macrophage Raw 264.7 cell line. 物理化学性质： CAS号：1354825-58-3 常用中文名：WEHI-345 常用英文名：WEHI-345 分子式：C22H23N7O 分子量：401.464 密度：1.3±0.1 g/cm3 沸点：709.0±60.0 °C at 760 mmHg 熔点：N/A 闪点：382.6±32.9 °C 储存条件：2-8℃ |
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：WEHI-345
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：WEHI-345
- 价格： ￥9400.9/50mg ￥2600.9/10mg ￥15000.9/100mg ￥1650.9/5mg
- 纯度：98.0%
- 备货期：10天
- 联系人：阿拉丁
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参考价格：$132/10mM*1mLinDMSO