WEHI-345

• 常用名: WEHI-345
• 英文名: WEHI-345
• CAS号: 1354825-58-3
• 分子量: 401.464
• 密度: 1.3±0.1 g/cm3
• 沸点: 709.0±60.0 °C at 760 mmHg
• 分子式: C₂₂H₂₃N₇O
• 熔点: N/A
• 闪点: 382.6±32.9 °C

WEHI-345用途

WEHI-345是一种有效的选择性RIPK2, IC50为0.13 μM。

WEHI-345名称

• 中文名: N-[2-[4-氨基-3-(4-甲基苯基)-1H-吡唑并[3,4-D]嘧啶-1-基]-2-甲基丙基]-4-吡啶甲酰胺
• 英文名: N-{2-[4-Amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl}isonicotinamide

WEHI-345生物活性

• 描述: WEHI-345是一种有效的选择性RIPK2, IC50为0.13 μM。
• 相关类别:
  信号通路 >> 细胞凋亡 >> RIP激酶
  研究领域 >> 癌症
• 参考文献:

  [1]. Nachbur U, et al. A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production. Nat Commun. 2015 Mar 17;6:6442.

WEHI-345物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 709.0±60.0 °C at 760 mmHg
• 分子式: C₂₂H₂₃N₇O
• 分子量: 401.464
• 闪点: 382.6±32.9 °C
• 精确质量: 401.196411
• LogP: 2.12
• InChIKey: LEBSTCDZKUSVOY-UHFFFAOYSA-N
• SMILES: Cc1ccc(-c2nn(C(C)(C)CNC(=O)c3ccncc3)c3ncnc(N)c23)cc1
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.687
• 储存条件: 2-8℃

WEHI-345靶点实验

查看更多实验

实验名称：Diffuse intrinsic pontine glioma (SU-DIPG-XVII) cell line screen of MIPE5.0 library: ... 来源：15316 靶标：N/A External Id：s-dipg-DIPG17_CTG48h_mipe5_0-1

实验名称：qHTS drug screen for cell cycle checkpoint inhibitors in PARPi-resistant BRCA-mutant ... 来源：NCGC External Id：FGL-PARP_PEO-CTG96h-MIPE5.0-p1

实验名称：Diffuse intrinsic pontine glioma (SU-DIPG-XXV) cell line screen of MIPE5.0 library: v... 来源：15316 靶标：N/A External Id：s-dipg-DIPG25-MIPE5.0-CTF48h-p1

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-SW13-72hr

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line NCI-H295R 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-H295R-72hr

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Metabolic stability in human liver microsomes assessed as clearance at 1 uM by LC/MS/... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5136576

实验名称：Diffuse intrinsic pontine glioma (SU-DIPG-XIII) cell line screen of MIPE5.0 library: ... 来源：15316 靶标：N/A External Id：s-dipg-DIPG13_CTG48h_mipe5_0-1

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

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WEHI-345英文别名

• N-{2-[4-Amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl}isonicotinamide
• WEHI-345