PI1840
更新时间：2024-01-28 10:14:18
| 常用名 | PI-1840 | CAS号 | 1401223-22-0 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： PI-1840 is a potent and selective inhibitor for chymotrypsin-like (CT-L) (IC50 value = 27 ± 0.14 nM) over trypsin-like and peptidylglutamyl peptide hydrolyzing (IC50 values >100 μM) activities of the proteasome. IC50 value: 27 nM(CT-L activities of the proteasome) [1]Target: CT-L inhibitorin vitro: PI-1840 is over 100-fold more selective for the constitutive proteasome over the immunoproteasome. Mass spectrometry and dialysis studies demonstrate that PI-1840 is a noncovalent and rapidly reversible CT-L inhibitor. In intact cancer cells, PI-1840 inhibits CT-L activity, induces the accumulation of proteasome substrates p27, Bax, and IκB-α, inhibits survival pathways and viability, and induces apoptosis. Furthermore, PI-1840 sensitizes human cancer cells to the mdm2/p53 disruptor, nutlin, and to the pan-Bcl-2 antagonist BH3-M6 [1].in vivo: PI-1840 but not bortezomib suppresses the growth in nude mice of human breast tumor xenografts [1]. 物理化学性质： CAS号：1401223-22-0 常用中文名：PI-1840 常用英文名：PI 1840 分子式：C22H26N4O3 分子量：394.46700 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20℃ |
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：PI-1840
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：PI 1840
- 价格： ￥875.9/10mg ￥1750.9/25mg ￥2780.9/50mg ￥4428.9/100mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$143/10mM*1mLinDMSO