PI-1840

• 常用名: PI-1840
• 英文名: PI 1840
• CAS号: 1401223-22-0
• 分子量: 394.46700
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₆N₄O₃
• 熔点: N/A
• 闪点: N/A

PI-1840用途

PI-1840是蛋白酶体chymotrypsin-like (CT-L)高效选择性性抑制剂,IC50值为27nM。

PI-1840名称

• 中文名: PI-1840
• 英文名: N-isopropyl-2-(4-propylphenoxy)-N-(((3-pyridin-3-yl)-1,2,4-oxadiazol-5-yl)methyl)acetamide

PI-1840生物活性

• 描述: PI-1840是蛋白酶体chymotrypsin-like (CT-L)高效选择性性抑制剂,IC50值为27nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 蛋白酶体
  研究领域 >> 癌症
• 参考文献:

  [1]. Kazi A, et al. Discovery of PI-1840, a novel noncovalent and rapidly reversible proteasome inhibitor with anti-tumor activity. J Biol Chem. 2014 Apr 25;289(17):11906-15.

PI-1840物理化学性质

• 分子式: C₂₂H₂₆N₄O₃
• 分子量: 394.46700
• 精确质量: 394.20000
• PSA: 81.35000
• LogP: 3.90010
• InChIKey: ZVVXAODXPVWGMF-UHFFFAOYSA-N
• SMILES: CCCc1ccc(OCC(=O)N(Cc2nc(-c3cccnc3)no2)C(C)C)cc1
• 外观性状: 粉末
• 储存条件: -20℃

PI-1840靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Stability in human liver microsomes assessed as drug degradation at 1 uM measured wit... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4328852

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Inhibition of human chymotrypsin-like activity of 20S constitutive proteasome at 10 u... 来源：ChEMBL 靶标：Proteasome subunit beta type-5 External Id：CHEMBL4328851

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytotoxicity against human MDA-MB-468 cells assessed as decrease in cell survival aft... 来源：ChEMBL 靶标：MDA-MB-468 External Id：CHEMBL2352039

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

共36条，当前第1页，共4页

1

2

3

4

PI-1840英文别名

• PI-1840