SB242235
更新时间：2024-10-22 14:37:47
| 常用名 | 4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶 | CAS号 | 193746-75-7 |
|---|---|---|---|
| 价格 | ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 uM.IC50 Value: 1.0 uM [1]Target: p38 MAPKin vitro: SB 242235 inhibited intracellular p38 activity, human chondrocytes were treated with different doses of SB 242235 prior to stimulation with IL-1_ for 15 min. MAPKAP K2 was then isolated from these cells and assayed using HSP27 as a substrate. SB 242235 dose-dependently inhibited the activation of MAPKAP K2 with an IC50 of 1.0 uM [1].in vivo: SB-242235 demonstrates generally favourable pharmacokinetic properties in all species examined(including rat, dog and monkey). Systemic plasma clearance was high in rat, but in the non-rodent species SB-242235 demonstrated low to moderate clearance with plasma half-lives > 4h. Oral bioavailability in each preclinical species was high. In rat and monkey, SB-242235 demonstrated non-linear elimination kinetics that manifested as a decrease in clearance with increasing dose and apparent oral bioavailability > 100% at high oral doses [2].In the skin of SKH-1 hairless mice, SB242235, prior to UVB irradiation, blocked activation of the p38 MAPK cascade, and abolished MAPKAPK-2 kinase activity and phosphorylation of HSP27. Moreover, SB242235 inhibited expression of the pro-inflammatory cytokines interleukin (IL)-6 and KC (murine IL-8) and COX-2 [3]. The preclinical pharmacokinetics of SB-242235 have been described previously. The present studies were conducted to describe the in vitro metabolic rates and routes of SB-242235 metabolism, to characterize its in vivo preclinical metabolism, and to use these data to aid in the prediction of the pharmacokinetic behaviour of SB-242235 in man [4]. 物理化学性质： CAS号：193746-75-7 常用中文名：4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶 常用英文名：SB 242235 分子式：C19H20FN5O 分子量：353.393 密度：1.3±0.1 g/cm3 沸点：568.4±60.0 °C at 760 mmHg 熔点：N/A 闪点：297.5±32.9 °C 储存条件：2-8℃ |
- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：4-(4-(4-氟苯基)-1-(哌啶-4-基)-1H-咪唑-5-基)-2-甲氧基嘧啶
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：化源网
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：SB242235
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海脉铂医药科技有限公司
- 上海市 上海市 嘉定区
- 产品名：SB 242235
- 价格： ￥13333.0/50mg
- 纯度：98.0%
- 备货期：2天
- 联系人：李先生
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：SB 242235
- 价格： ￥8800.9/100mg ￥850.9/5mg ￥1450.9/10mg ￥3050.9/25mg
- 纯度：99.0%
- 备货期：10天
- 联系人：阿拉丁
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4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶生产厂家
参考价格：$198/10mM*1mLinDMSO