4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶

• 常用名: 4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶
• 英文名: SB 242235
• CAS号: 193746-75-7
• 分子量: 353.393
• 密度: 1.3±0.1 g/cm3
• 沸点: 568.4±60.0 °C at 760 mmHg
• 分子式: C₁₉H₂₀FN₅O
• 熔点: N/A
• 闪点: 297.5±32.9 °C

用途

SB-242235是p38 MAP激酶抑制剂，IC50为1.0 uM。

名称

• 中文名: 4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶
• 英文名: 4-[5-(4-fluorophenyl)-3-piperidin-4-ylimidazol-4-yl]-2-methoxypyrimidine

生物活性

• 描述: SB-242235是p38 MAP激酶抑制剂,IC50为1.0 uM。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 癌症
• 参考文献:

  [1]. Badger, A.M., et al., Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures. Osteoarthritis Cartilage, 2000. 8(6): p. 434-43.

  [2]. Ward, K.W., et al., SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. I: preclinical pharmacokinetics. Xenobiotica, 2002. 32(3): p. 221-33.

  [3]. Kim, A.L., et al., Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice. J Invest Dermatol, 2005. 124(6): p. 1318-25.

  [4]. Ward, K.W., et al., SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. II: in vitro and in vivo metabolism studies and pharmacokinetic extrapolation to man. Xenobiotica, 2002. 32(3): p. 235-50.

物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 568.4±60.0 °C at 760 mmHg
• 分子式: C₁₉H₂₀FN₅O
• 分子量: 353.393
• 闪点: 297.5±32.9 °C
• 精确质量: 353.165192
• PSA: 64.86000
• LogP: 3.01
• InChIKey: PDTYLGXVBIWRIM-UHFFFAOYSA-N
• SMILES: COc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCNCC2)n1
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.662
• 储存条件: 2-8℃

靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Inhibition of TNF-alpha production in rat joint after oral administration at 3 mg/Kg;... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL877366

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

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英文别名

• 4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxypyrimidine
• Kinome_3169
• HMS3244I17
• HMS3244I18
• HMS3244J17
• 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]-2-methoxypyrimidine
• 4-(4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine
• SB 242235