| 常用名 | 胺碘酮 | CAS号 | 1951-25-3 |
|---|---|---|---|
| 价格 | ¥需询单/1g | 纯度 | 98.0% |
| 备货期 | 1天 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM. Target: Potassium ChannelAmiodarone shows beta blocker-like and potassium channel blocker-like actions on the SA and AV nodes, increases the refractory period via sodium- and potassium-channel effects, and slows intra-cardiac conduction of the cardiac action potential, via sodium-channel effects. Amiodarone (2-butyl, 3-(4-diethylaminoethoxy, 3,5-diiodo, benzoyl) benzofuran hydrochloride), an anti-anginal drug which causes coronary dilatation and depresses myocardial oxygen consumption, was found to protect anaesthetized guinea-pigs against ouabain-induced ventricular fibrillation.2. A 5% (73.4 mM) solution of amiodarone had no local anaesthetic action on guinea-pig skin [1]. Amiodarone proved safe in patients with severe congestive heart failure and severe myocardial damage. Its clinical efficacy was related to its electrophysiologic properties and to two unique properties: its wide safety margin and its cumulative effect [2]. 物理化学性质: CAS号:1951-25-3 常用中文名:胺碘酮 常用英文名:Amiodarone 分子式:C25H29I2NO3 分子量:645.31200 密度:1.58 g/cm3 沸点:635.1ºC at 760 mmHg 熔点:156ºC 闪点:337.9ºC 储存条件:库房通风低温干燥 |