盐酸托烷司琼
更新时间：2024-07-15 12:29:57
采购访问：21次
| 常用名 | 盐酸托烷司琼 | CAS号 | 105826-92-4 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.IC50 value: 70.1 ± 0.9 nMTarget: 5-HT3 receptor; α7-nicotinic receptorin vitro: Retinal ganglion cells(RGCs) pretreated with 100 nM tropisetron before glutamate increased cell survival to an average of 105% compared to controls. Inhibition studies using the alpha7 nAChR antagonist, MLA (10 nM), support the hypothesis that tropisetron is an effective neuroprotective agent against glutamate-induced excitotoxicity; mediated by α7 nAChR activation. Tropisetron had no discernible effects on pAkt levels but significantly decreased p38 MAPK levels associated with excitotoxicity from an average of 15 ng/ml to 6 ng/ml [2]. Tropisetron, but not granisetron, significantly inhibits the phosphatase activity of calcineurin, over-expresses the CB(1) receptors at both transcriptional and protein levels, and reduces cAMP content in cerebellar granule neurons (CGNs) [4].in vivo: Animals were treated intracerebroventricularly with tropisetron, mCPBG (selective 5-HT3 receptor agonist) or mCPBG plus tropisetron on days 1, 3, 5 and 7. Tropisetron significantly diminished the elevated levels of these markers and reversed the cognitive deficit. Interestingly, tropisetron was also found to be a potent inhibitor of calcineurin phosphatase activity [1]. tropisetron (5mg/kg/day) plus mCPBG (10mg/kg/day), and granisetron (5mg/kg/day) intraperitoneally on days 3-35 post-immunization. Treatment with tropisetron and granisetron markedly suppressed the clinical symptoms of EAE (p 物理化学性质： CAS号：105826-92-4 常用中文名：盐酸托烷司琼 常用英文名：Tropisetron hydrochloride 分子式：C17H21ClN2O2 分子量：320.814 密度：N/A 沸点：448.5ºC at 760 mmHg 熔点：283-285ºC 闪点：225ºC 储存条件：2-8°C |
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- 产品名：盐酸托烷司琼
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 盼得（上海）国际贸易有限公司
- 上海市 上海市 徐汇区
- 产品名：盐酸托烷司琼
- 价格： ￥需询单/500g ￥需询单/1kg ￥需询单/25kg ￥需询单/200kg
- 纯度：0.0%
- 备货期：需询单
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参考价格：$66/10mM*1mLinDMSO