AZD3839
更新时间：2026-01-11 10:52:01
采购访问：23次
| 常用名 | AZD3839自由基 | CAS号 | 1227163-84-9 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.target: BACE1, β-secretase enzyme [1]IC50: 23.6 uM [1]AZD3839 dissolved in 0.33% dimethylsulfoxideIn vitro: AZD3839 and its metabolites M1 and M2 inhibited CYP3A4 in a reversible and an irreversible manner, which could affect not only the metabolism of other CYP3A4 substrates but also the metabolism of AZD3839 itself. [1]In vivo: AZD3839 is dissolved in 0.3 M gluconic acid, adjusted to pH 3. Solutions of 0.75, 2.5, and 7.5 mg/ml are prepared and are administered orally by gavage at 2 ml/kg body weight at 1.5, 5, and 15 mg/kg (study 1) and 15 mg/kg (study 2). [1]AZD3839 effectively reduces the levels of Aβ in brain, CSF, and plasma in several preclinical species. [2] 物理化学性质： CAS号：1227163-84-9 常用中文名：AZD3839自由基 常用英文名：AZD3839 分子式：C24H16F3N5 分子量：431.413 密度：1.4±0.1 g/cm3 沸点：596.3±60.0 °C at 760 mmHg 熔点：N/A 闪点：314.4±32.9 °C 储存条件：-20℃ |
上海念兴实业有限公司
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- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：AZD3839
- 价格： ￥1899.9/10mg ￥299.9/1mg ￥3399.9/25mg ￥999.9/5mg
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$172/10mM*1mLinDMSO