N-(4-丁基-2-甲基苯基)乙酰胺
更新时间：2024-07-15 12:32:05
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| 常用名 | N1-(4-丁基-2-甲基苯基)乙酰胺 | CAS号 | 143360-00-3 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： SMIP004 is a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells, it was found to downregulate SKP2 and to stabilize p27.IC50 Value: 1.09 uM (MTT assay in LNCaP-S14 cells) [1]Target: Apoptosis inducer; SKP2in vitro: Whereas SMIP012 and 016 were moderately toxic in normal fibroblasts, SMIPs 001 and 004 showed substantial cancer cell specificity being at least five times more potent in LNCaP-S14 than in IMR90 cells , treatment with either MG132 or SMIP004 increased p27 half-life to > 6 h [1]. Both SMIP001 and 004 led to a strong increase in the recruitment of p27 to CDK2, while SMIP001 also slightly increased coprecipitation of p21 (Figure 6c). SMIP004 also reduced the amounts of cyclins E and A retrieved with CDK2. This was paralleled by a marked downregulation of cyclins E and A upon SMIP004 treatment. SMIP004 decreased the levels of positive cell cycle regulators, upregulated cyclin-dependent kinase inhibitors, and resulted in G1 arrest, inhibition of colony formation in soft agar, and cell death [2].in vivo: SMIP004 potently inhibits the growth of prostate and breast cancer xenografts in mice [2].Clinical trial: 物理化学性质： CAS号：143360-00-3 常用中文名：N1-(4-丁基-2-甲基苯基)乙酰胺 常用英文名：SMIP004 分子式：C13H19NO 分子量：205.29600 密度：1.003g/cm3 沸点：343ºC at 760mmHg 熔点：N/A 闪点：206.1ºC 储存条件：2-8℃ |
上海念兴实业有限公司
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- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：SMIP004
- 价格： ￥1235.0/5mg ￥5812.0/25mg ￥需询单/1g ￥2438.0/10mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$245/10mM*1mLinDMSO