茚地那韦
更新时间：2024-07-15 12:32:22
采购访问：14次
| 常用名 | 茚地那韦 | CAS号 | 150378-17-9 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Indinavir(MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.Target: HIV ProteaseIndinavir(MK-639) is a protease inhibitor used as a component of highly active antiretroviral therapy (HAART) to treat HIV infection and AIDS.MK-639 appears to have significant dose-related antiviral activity and is well tolerated [1]. Inhibition constants (K(i)) of the antiviral drug indinavir for the reaction catalyzed by the mutant enzymes were about threefold and 50-fold higher for PR(L24I) and PR(I50V), respectively, relative to PR and PR(G73S). The dimer dissociation constant (K(d)) was estimated to be approximately 20 nM for both PR(L24I) and PR(I50V), and below 5 nM for PR(G73S) and PR. Crystal structures of the mutants PR(L24I), PR(I50V) and PR(G73S) were determined in complexes with indinavir, or the p2/NC substrate analog at resolutions of 1.10-1.50 Angstrom [2]. 物理化学性质： CAS号：150378-17-9 常用中文名：茚地那韦 常用英文名：Indinavir 分子式：C36H47N5O4 分子量：613.789 密度：1.2±0.1 g/cm3 沸点：831.6±75.0 °C at 760 mmHg 熔点：150-153ºC 闪点：456.8±37.1 °C 储存条件：2-8℃ |
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