(2S)-2-((2-氨基-6-氧代-1H-嘌呤-9(6H)-基)甲氧基)-3-羟丙基2-氨基-3-甲基丁酸酯盐酸盐
更新时间：2024-07-15 12:32:54
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| 常用名 | 缬更昔洛韦盐酸盐 | CAS号 | 175865-59-5 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Valganciclovir (hydrochloride), the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir. Valganciclovir is an antiviral medication used to treat cytomegalovirus infections.IC50 Value: Target: CMVin vitro: In cell culture model systems using Caco-2 cells for PEPT1 and SKPT cells for PEPT2, valganciclovir inhibited glycylsarcosine transport mediated by PEPT1 and PEPT2 with K(i) values (inhibition constant) of 1.68+/-0.30 and 0.043+/- 0.005 mM, respectively. The inhibition by valganciclovir was competitive in both cases [1].in vivo: 37 patients were enrolled; 19 patients received treatment with VGV and 18 patients received treatment with GCV. The VGV was not inferior in efficacy to GCV as pre-emptive therapy, with rates of viral clearance at 28 days of 89.5% and 83%, respectively (P-value for non-inferiority = 0.030). Toxicities were similar between the 2 arms. No patients developed CMV disease [2]. Patients being treated with an alemtuzumab-containing regimen received prophylaxis with either valaciclovir 500 mg orally daily orvalganciclovir 450 mg orally twice daily. None of the 20 patients randomized to valganciclovir experienced CMV reactivation (P = .004) [3]. 物理化学性质： CAS号：175865-59-5 常用中文名：缬更昔洛韦盐酸盐 常用英文名：Valganciclovir Hydrochloride 分子式：C14H23ClN6O5 分子量：390.823 密度：N/A 沸点：629.1ºC at 760 mmHg 熔点：N/A 闪点：N/A 储存条件：-20°C |
上海念兴实业有限公司
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- 产品名：(2S)-2-((2-氨基-6-氧代-1H-嘌呤-9(6H)-基)甲氧基)-3-羟丙基2-氨基-3-甲基丁酸酯盐酸盐
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
- 武汉敬康恩生物医药科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：Valganciclovir hydrochloride
- 价格： ￥需询单/1mg
- 纯度：98.0%
- 备货期：1天
- 联系人：周经理
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参考价格：$145/10mM*1mLinDMSO