Taltobulin(trifluoroacetate)
更新时间：2024-07-15 12:33:55
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| 常用名 | Taltobulin trifluoroacetate | CAS号 | 228266-41-9 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Taltobulin trifluoroacetate (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.IC50 value:Target: tubulinin vitro: HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure [1]. In all cell lines tested, HTI-286 was a potent inhibitor of proliferation and induced marked increases in apoptosis. Despite similar transcriptomic changes regarding cell death and cell cycle regulating genes after exposure to HTI-286 or docetaxel, array analysis revealed distinct molecular signatures for both compounds [2].in vivo: Intravenous administration of HTI-286 significantly inhibited tumor growth in vivo (rat allograft model) [1]. HTI-286 significantly inhibited growth of PC-3 and LNCaP xenografts and retained potency in PC-3dR tumors. Simultaneous castration plus HTI-286 therapy was superior to sequential treatment in the LNCaP model [2]. 物理化学性质： CAS号：228266-41-9 常用中文名：Taltobulin trifluoroacetate 常用英文名：Taltobulin trifluoroacetate 分子式：C29H44F3N3O6 分子量：587.671 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃ |
上海念兴实业有限公司
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- 产品名：Taltobulin trifluoroacetate
- 价格： ￥4100.9/10mg ￥2750.9/5mg
- 纯度：99.0%
- 备货期：10天
- 联系人：阿拉丁
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参考价格：$465/10mM*1mLinDMSO