GA-017
更新时间：2024-07-15 12:33:59
采购访问：12次
| 常用名 | GA-017 | CAS号 | 2351906-74-4 |
|---|---|---|---|
| 价格 | 纯度 | 98.82% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： GA-017 (GA017) is a potent, selective, ATP-competitive LATS kinase (LATS1/2) inhibitor with IC50 of 4.10/3.92 nM, respectively, promotes cell growth.GA-017 increases the number and size of spheroids of various cell-types in both scaffold-based and scaffold-independent cultures.GA-017 also enhances the ex vivo formation of mouse intestinal organoids.GA-017 facilitates the growth of spheroids and organoids by stabilizing and translocating YAP/TAZ into the cell nucleus.GA-017 inhibits the Hippo pathway to promote YAP/TAZ stabilization and nuclear translocation.GA-017 induces expression of Hippo pathway-related genes such as ANKRD1, CYR61, and CTGF in SKOV3 cells in a time- and dose-dependent manner.GA-017 inhibited the activity of 16 kinases of the AGC family at 100 nM against a panel of 321 diverse kinases.The serine/threonine protein kinases LATS (LATS1/2) phosphorylate YAP/TAZ, key effectors of the growth- and proliferation-regulating Hippo signaling pathway. 物理化学性质： CAS号：2351906-74-4 常用中文名：GA-017 常用英文名：GA-017 分子式：C18H21N3O4 分子量：343.383 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A |
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- 产品名：GA-017
- 价格： ￥3400.9/10mg ￥15000.9/100mg ￥6200.9/25mg ￥2200.9/5mg
- 纯度：98.0%
- 备货期：10天
- 联系人：阿拉丁
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