化合物VT104
更新时间：2024-07-15 12:34:07
采购访问：25次
| 常用名 | VT104 | CAS号 | 2417718-25-1 |
|---|---|---|---|
| 价格 | 纯度 | 99.5% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： VT104 (VT-104) is a specific small molecule inhibitor of YAP/TAZ-TEAD-dependent transcription with IC50 of 10.4 nM in YAP reporter assay, pan-TEAD palmitoylation inhibitor.VT104 inhibited palmitoylation of both endogenous TEAD1, TEAD3 proteins in cells.VT104 decreased the levels of palmitoylated TEAD3 and TEAD4 and increased the levels of unpalmitoylated TEAD3 and TEAD4 in the human mesothelioma cell line NCI-H2373.VT104 exhibited inhibitory activity in more mesothelioma cell lines than the TEAD1-selective inhibitor VT103.VT104 (oral administration of 10 and 3 mg/kg) has very strong antitumor efficacy in the human mesothelioma NCI-H226 CDX model, with no effect on body weight gain. 物理化学性质： CAS号：2417718-25-1 常用中文名：VT104 常用英文名：VT104 分子式：C25H19F3N2O 分子量：420.435 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A |
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