3-(2-羟基苯基)-6-(3-硝基苯基)-3,4-二氢嘧啶-2(1H)-酮
更新时间：2024-07-15 12:34:59
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| 常用名 | 冰素 | CAS号 | 36945-98-9 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Icilin(AG 3-5) is a synthetic super-agonist of TRPM8 ion channel.IC50 value:Target: TRPM8in vitro: icilin, a super-cooling agent, down-regulated the expression of cell cycle signature genes and caused G1 arrest in PC-3 prostate cancer cells. icilin affected cell cycle-related transcriptional modules and identified E2F1 transcription factor as a target master regulator of icilin. icilin reduced the activity and expression levels of E2F1 [1]. Icilin concentration-response curves were significantly shifted to the right when pH was lowered from 7.3 to 6.9, whereas those with menthol were unaltered in solutions of pH 6.1 [2]. Icilin modulated the expression level of various cell cycle regulators at transcription or post-translational levels. In addition, icilin activated JNK and p38 kinase pathways, but not ERK [4].in vivo: Rats injected with icilin (0.5, 1, 2.5, 5mg/kg, i.p.) displayed dose-related WDS that were inhibited by pretreatment with a fixed dose of clonidine (0.15 mg/kg, s.c.). Shaking behavior caused by a fixed dose (2.5mg/kg) of icilin was also inhibited in a dose-related manner by clonidine pretreatment (0.03-0.15 mg/kg, s.c.) and reduced by clonidine posttreatment (0.15 mg/kg, s.c.) [3]. 物理化学性质： CAS号：36945-98-9 常用中文名：冰素 常用英文名：IcilinAG-3-5 分子式：C16H13N3O4 分子量：311.292 密度：1.4±0.1 g/cm3 沸点：594.8±50.0 °C at 760 mmHg 熔点：200-208ºC 闪点：313.5±30.1 °C 储存条件：-20℃ |
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- 产品名：IcilinAG-3-5
- 价格： ￥1510.9/100mg ￥300.9/10mg ￥590.9/25mg ￥944.9/50mg
- 纯度：96.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$86/10mM*1mLinDMSO