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5β,6β-epoxy Cholestanol

更新时间:2024-07-15 12:35:09 采购访问:11次

常用名 5β,6β-epoxy Cholestanol CAS号 4025-59-6
价格 纯度 98.0%
备货期 10天 库存 现货
 产品详情(用途,包装等)
用途:
Cholesterol 5beta,6beta-epoxide is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. [1] [2] Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. [3] 5β,6β-epoxycholestanol has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue. [4] References: [1]. Pulfer, MK, and Murphy, RC Formation of bioactive oxygen sterols during ozonolysis of cholesterol present in lung surfactants. Journal of Biochemistry 279(25), 26331-26338 (2004). [2]. Aringer, L. and Eneroth, P. In vitro formation and metabolism of cholesterol and β-sitosterol 5,6-epoxides. J. Lipid Research. 15(4), 389-398 (1974).[3]. Lordan, S., O'Brien, NM, and Mackrill, JJ Calcium in 7β-hydroxycholesterol and cholesterol-5β,6β-epoxide-induced apoptosis. J. Biochemistry. Moore. poison. 23(5), 324-332 (2009).[4]. Garcia-Cruset, S., Carpenter, KL, Guardiola, F. et al. Oxysterol profiles of normal human arteries, fatty streaks, and advanced lesions. free radicals. reservoir. 35(1), 31-41 (2001).
物理化学性质:
CAS号:4025-59-6
常用中文名:5β,6β-epoxy Cholestanol
常用英文名:(3-beta,5-beta,6-beta)-5,6-Epoxycholestan-3-ol
分子式:C27H46O2
分子量:402.65300
密度:1.04g/cm3
沸点:497.7ºC at 760 mmHg
熔点:N/A
闪点:200.9ºC
储存条件:-20°C, 密封, 干燥

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