Lersivirine
更新时间：2026-02-03 12:53:19
采购访问：15次
| 常用名 | 3-氰基-5-[[3,5-二乙基-1-(2-羟基乙基)-1H-吡唑-4-基]氧基]苯腈 | CAS号 | 473921-12-9 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Lersivirine(UK-453061) is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI, IC50=119 nM) with a unique resistance profile that exhibits potent antiretroviral activity against wild-type human immunodeficiency virus and clinically relevant NNRTI-resistant strains.IC50 value: 0.119 uM [1]Target: NNRTIUK-453061(Compound 5) demonstrated excellent activity against large panels of wild type and drug-resistant HIV consistent with the encouraging profile demonstrated against the isolated RT enzymes. Compound 5 can be readily prepared in multi-gram quantities by virtue of the efficient and concise synthetic route. The compound also has good aqueous solubility and formulation characteristics which enable further in vivo evaluation. Clinical trials evaluating the potential of 5 (UK-453,061, lersivirine) to treat HIV infection are proceeding and further progress will be reported in due course [1].At clinically relevant lersivirine doses (500-1,000 mg total daily dose), the mean plasma exposure of midazolam was reduced in a dose-dependent manner by 20-36 %. Co-administration of lersivirine 1,000 mg QD with OCs had minor PK effects, increasing ethinylestradiol exposure by 10 % and reducing levonorgestrel exposure by 13 % [2]. Mated Crl:CD1(ICR) mice were administered 0, 150, 350, and 500 mg/kg lersivirine once daily by oral gavage on gestation days 6 to 17, followed by cesarean section on gestation day 18. The first 2 days of dosing for the high-dose group were done at 250 mg/kg to allow induction of hepatic metabolizing enzymes, after which the dose was increased to 500 mg/kg/day [3]. 物理化学性质： CAS号：473921-12-9 常用中文名：3-氰基-5-[[3,5-二乙基-1-(2-羟基乙基)-1H-吡唑-4-基]氧基]苯腈 常用英文名：Lersivirine 分子式：C17H18N4O2 分子量：310.350 密度：1.2±0.1 g/cm3 沸点：455.4±45.0 °C at 760 mmHg 熔点：N/A 闪点：229.2±28.7 °C 储存条件：2-8℃ |
上海念兴实业有限公司
认证状态：已认证供应商
商品数：403768件
电话：18916513247
地址：2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai
地区： 上海市 上海市 普陀区
联系人：小陈
联系人电话：0086-021-52280163
邮件：sales@echemcloud.com
网址：http://www.echemcloud.com
主要市场：
年贸易额：
外贸占销售比例：
主要合作伙伴：
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：Lersivirine
- 价格： ￥796.0/5mg ￥6053.0/10mg ￥需询单/1g ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：Lersivirine
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
查看所有供应商和价格请点击：
3-氰基-5-[[3,5-二乙基-1-(2-羟基乙基)-1H-吡唑-4-基]氧基]苯腈生产厂家
参考价格：$158/10mM*1mLinDMSO