CP-809101?
更新时间：2024-07-15 12:35:25
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| 常用名 | 6'-(3-氯苄基氧基)-3,4,5,6-四氢-2H-[1,2']联吡嗪 | CAS号 | 479683-64-2 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： CP-809101 is a potent and selective 5-HT2C receptor agonist with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors respectively. IC50 Value: 9.96(pEC50 for 5-HT2C); 7.19(pEC50 for 5-HT2B); 6.81(pEC50 for 5-HT2A)Target: 5-HT2C ReceptorCP-809101 is a potent, functionally selective 5-HT2C agonist that displays approximately 100% efficacy in vitro. The aim of the present studies was to assess the efficacy of a selective 5-HT2C agonist in animal models predictive of antipsychotic-like efficacy and side-effect liability. Similar to currently available antipsychotic drugs, CP-809101 dose-dependently inhibited conditioned avoidance responding (CAR, ED50 = 4.8 mg/kg, sc). CP-809101 antagonized both PCP- and d-amphetamine-induced hyperactivity with ED50 values of 2.4 and 2.9 mg/kg (sc), respectively and also reversed an apomorphine induced-deficit in prepulse inhibition. At doses up to 56 mg/kg, CP-809101 did not produce catalepsy. Thus, the present results demonstrate that the 5-HT2C agonist, CP-809101, has a pharmacological profile similar to that of the atypical antipsychotics with low extrapyramidal symptom liability. CP-809101 was inactive in two animal models of antidepressant-like activity, the forced swim test and learned helplessness. 物理化学性质： CAS号：479683-64-2 常用中文名：6'-(3-氯苄基氧基)-3,4,5,6-四氢-2H-[1,2']联吡嗪 常用英文名：CP-809101 分子式：C15H17ClN4O 分子量：304.77 密度：1.3±0.1 g/cm3 沸点：486.6±45.0 °C at 760 mmHg 熔点：N/A 闪点：248.1±28.7 °C 储存条件：2-8℃ |
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- 产品名：CP-809101
- 价格： ￥4150.0/50mg ￥需询单/1g ￥需询单/1g ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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6'-(3-氯苄基氧基)-3,4,5,6-四氢-2H-[1,2']联吡嗪生产厂家
参考价格：$134/10mg