苯并[d]异恶唑-3-基甲磺酰胺
更新时间：2024-07-15 12:36:19
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| 常用名 | 唑尼沙胺 | CAS号 | 68291-97-4 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Zonisamide is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug.Target: Calcium channel inhibitor; Sodium channel inhibitorZonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures for adults; infantile spasm, mixed seizure types of Lennox-Gastaut syndrome, myoclonic, and generalized tonic clonic seizure. Zonisamide is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug. It has shown activity in various animal models of epilepsy, and although a detailed mode of action awaits clarification it appears to block the propagation/spread of seizure discharges and to suppress the epileptogenic focus [1].Zonisamide 500 mg/day was significantly superior to placebo in reducing the frequency of complex partial seizures (-51% versus -16%), all partial seizures and all seizures, with dose-dependent benefit provided over a 100-500 mg/day dose range. Supporting trials have confirmed significant increases in reduction in median seizure frequency (up to 41%) and responder rates (35-42%) compared with placebo following zonisamide 400-600 mg/day, enabling 20-27% of patients to attain >or=75% reduction in seizure frequency [2].Clinical indications: Epilepsy; Lewy body dementia; Parkinsons diseaseToxicity: Anorexia; Somnolence; Dizziness; Irritability; Confusional state; Depression; Diplopia; Memory impairment 物理化学性质： CAS号：68291-97-4 常用中文名：唑尼沙胺 常用英文名：Zonisamide 分子式：C8H8N2O3S 分子量：212.226 密度：1.5±0.1 g/cm3 沸点：457.2±47.0 °C at 760 mmHg 熔点：275°C dec. 闪点：230.3±29.3 °C 储存条件：通风低温干燥 |
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- 产品名：唑尼沙胺
- 价格： ￥271.9/1g ￥138.9/200mg ￥1004.9/25g ￥374.9/5g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$113/10mM*1mLinDMSO