N'-(1-(吡啶-2-基)亚乙基)氮杂环丁烷-1-硫代碳酰肼
更新时间：2024-07-15 12:36:28
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| 常用名 | NSC319726 | CAS号 | 71555-25-4 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： NSC319726 is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM); shows no inhibition for p53 wild-type cells.IC50 value: 8 nM [1]Target: mutant p53R175 reactivatorin vitro: For NSC319726, the effect was even greater as the IC50for the 175 mutant was 8 nM while the IC50 of the WT was not reached. NSC319726 did not induce WT p53 protein levels or transcriptional activity as common cytotoxic agents such as etoposide do in vitro. NSC319726 exhibited a much higher sensitivity for the MEF-p53R172H/R172H cell line as compared to the p53+/+ and p53-/- controls. NSC319726 treatment of a MEF cell line derived from p53R172H/R172H mice resulted in aloss of PAB240 immunoflouresence staining. in vivo: At a dose of 1mg/kg, tumor growth of the H460 (p53+/+) and MDAMB468 (p53R273W) xenografts was not inhibited relative to the vehicle control whereas tumor growth was significantly inhibited in the TOV112D (p53R175H) xenografts. When we lowered the dose ten-fold to 0.1 mg/kg in the TOV112D mice, we observed only a small difference in tumor growth inhibition demonstrating both a dosage effect of the drug and a larger therapeutic window.Taken together, these findings provide in vivo evidence for allele specific p53 mutant reactivation. 物理化学性质： CAS号：71555-25-4 常用中文名：NSC319726 常用英文名：NSC 319726 分子式：C11H14N4S 分子量：234.321 密度：1.3±0.1 g/cm3 沸点：367.7±34.0 °C at 760 mmHg 熔点：N/A 闪点：176.2±25.7 °C 储存条件：-20°C |
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- 上海阿拉丁生化科技股份有限公司
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- 产品名：NSC 319726
- 价格： ￥2059.9/25mg ￥574.9/5mg ￥5767.9/100mg ￥需询单/1g
- 纯度：95.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$92/10mM*1mLinDMSO