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cGAMP游离态

更新时间:2026-01-01 18:44:38 采购访问:16次

常用名 cGAMP CAS号 849214-04-6
价格 纯度 98.0%
备货期 10天 库存 现货
 产品详情(用途,包装等)
用途:
cGAMP(Cyclic GMP-AMP) is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA; STING ligand.Target:in vitro: cGAMP induced IFNβ RNA robustly even at concentrations as low as 10 nM. cGAMP was much more potent than c-di-GMP in inducing IFNβ based on ELISA assays. cGAMP was also more potent than c-di-GMP and c-di-AMP in activating IRF3. cGAMP binds to and activates STING to trigger the downstream signaling cascades [1]. On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF) [3]. cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs [4].in vivo: cGAMP can enhance the adaptive immune response to the model antigen ovalbumin in mice. cGAMP promotes antigen specific IgG and a balanced Th1/Th2 lymphocyte response in immunized mice [2].
物理化学性质:
CAS号:849214-04-6
常用中文名:cGAMP
常用英文名:cGAMP
分子式:C20H24N10O13P2
分子量:674.41100
密度:2.6±0.1 g/cm3
沸点:N/A
熔点:N/A
闪点:N/A
储存条件:2-8℃

供应商信息

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参考价格:$576/500ug
其他供应商价格:
2024-07-15 cGAMP游离态
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价格:¥1094.0
2022-05-12 cGAMP (Cyclic GMP-AMP; 3',3'-cGAMP)
价格:$需询单
2021-05-10 C-GPAP
价格:¥需询单

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