AzilsartanMedoxomil
更新时间：2024-07-15 12:37:09
采购访问：18次
| 常用名 | 阿齐沙坦奥美沙坦酯 | CAS号 | 863031-21-4 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. IC50 Value: 0.62 nM [2]Target: AT1 receptorin vitro: In aortic endothelial cells, azilsartan inhibited cell proliferation at concentrations as low as 1 μmol/l, whereas valsartan showed little or no antiproliferative effects at concentrations below 10 μmol/l. Antiproliferative effects of azilsartan were also observed in cells lacking AT1 receptors[1].in vivo: Oral administration of 0.1-3 mg/kg olmesartan medoxomil reduced blood pressure; however, only the two highest doses significantly reduced blood pressure 24h after dosing. ED(25) values were 0.41 and 1.3 mg/kg for azilsartan medoxomil and olmesartan medoxomil, respectively [2]. Over a longer treatment period of 24 weeks, azilsartan medoxomil showed sustained BP-lowering efficacy, with the reduction in 24-hour mean SBP at week 24 significantly greater with azilsartan medoxomil 40 or 80 mg once daily than with valsartan 320 mg once daily. Mean reductions from baseline in mean clinic SBP and DBP as well as DBP by ABPM were also significantly greater with azilsartan medoxomil 40 or 80 mg once daily than with valsartan[3]. In 4 randomized controlled trials (3 published to date), azilsartan medoxomil/chlorthalidone 40 mg/12.5 mg and 40 mg/25 mg reduced blood pressure (BP) significantly more than comparators did, including an approximately 5-mm Hg greater BP reduction than olmesartan medoxomil/hydrochlorothiazide 40 mg/25 mg and azilsartan medoxomil/hydrochlorothiazide [4].Clinical trial: Effect of Azilsartan on Aldosterone in Post-menopausal Females . Phase not specified 物理化学性质： CAS号：863031-21-4 常用中文名：阿齐沙坦奥美沙坦酯 常用英文名：Azilsartan medoxomil 分子式：C30H24N4O8 分子量：568.534 密度：1.5±0.1 g/cm3 沸点：748.0±70.0 °C at 760 mmHg 熔点：N/A 闪点：406.2±35.7 °C 储存条件：-20℃ |
上海念兴实业有限公司
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- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：阿齐沙坦奥美沙坦酯
- 价格： ￥需询单/100mg ￥需询单/10mg ￥需询单/1g ￥需询单/1mg
- 纯度：95.0%
- 备货期：需询单
- 联系人：王汐瑶
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：Azilsartan Medoxomil
- 价格： ￥121.9/100mg ￥823.9/1g ￥242.9/250mg ￥1445.9/1ml
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 江西瑞威尔生物科技有限公司
- 江西省 吉安市 峡江县
- 产品名：阿奇沙坦酯
- 价格： ￥需询单/1kg
- 纯度：98.0%
- 备货期：1天
- 联系人：李经理
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参考价格：￥748.8/5mg