N-[6-(2,5-二氢-2,5-二氧代-1H-吡咯-1-基)-1-氧代己基]-N-甲基-L-缬氨酰-L-缬氨酰基-(3R,4S,5S)-3-甲氧基-5-甲基-4-(甲氨基)庚酰基-(ΑR,ΒR,2S)-Β-甲氧基-Α-甲基-2-吡咯烷丙酰基-L-苯丙氨酸
更新时间：2024-07-15 12:37:09
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| 常用名 | McMMAF | CAS号 | 863971-19-1 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Mc-MMAF is a protective group-conjugated MMAF. MMAF is a more potent drug than Monomethyl auristatin E (MMAE), but is charged and relatively membrane-impermeable, is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.Target:MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism. 物理化学性质： CAS号：863971-19-1 常用中文名：McMMAF 常用英文名：McMMAF 分子式：C49H76N6O11 分子量：925.161 密度：1.2±0.1 g/cm3 沸点：1052.0±65.0 °C at 760 mmHg 熔点：N/A 闪点：590.1±34.3 °C 储存条件：2-8℃ |
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- 产品名：MC-MMAF
- 价格： ￥737.9/1mg ￥1218.9/5mg ￥2249.9/10mg
- 纯度：98.0%
- 备货期：10天
- 联系人：阿拉丁
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参考价格：$1832/10mM*1mLinDMSO