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Noscapine

更新时间:2025-09-14 11:48:31 采购访问:33次

常用名 那可丁 CAS号 128-62-1
价格 纯度 99.0%
备货期 10天 库存 现货
 产品详情(用途,包装等)
用途:
Noscapine is an orally administrable drug used worldwide for cough suppression, primarily mediated by its σ-receptor agonist activity, and possess anticancer activity.Target: σ-receptorin vitro: Noscapine is a phthalideisoquinoline alkaloid from opium, is a recently discovered anticancer drug and is currently under investigation in phase-I/II clinical trials for the treatment of leukemia and lymphoma. Noscapine causes few or no side effects and has been widely used as a cough suppressant in developing countries. Noscapine has been demonstrated to interact with microtubules. Interestingly, unlike many other microtubule-targeting agents such as Paclitaxel and Nocodazole, Noscapine does not obviously affect the total amount of microtubule polymers in cells; instead, it significantly increases the time microtubules spend in the pause state. The alteration of microtubule dynamics then activates the spindle checkpoint and arrests cell cycle progression at mitosis, leading to apoptotic cell death.
物理化学性质:
CAS号:128-62-1
常用中文名:那可丁
常用英文名:Noscapine
分子式:C22H23NO7
分子量:413.421
密度:1.3±0.1 g/cm3
沸点:565.3±50.0 °C at 760 mmHg
熔点:174-176ºC
闪点:295.7±30.1 °C
储存条件:-20℃

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参考价格:$66/10mM*1mLinDMSO
其他供应商价格:
2022-03-04 Noscapine
价格:¥259.0
2022-05-12 Narcotine
价格:$需询单

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