化合物HPPE
更新时间：2025-10-03 19:24:17
采购访问：6次
| 常用名 | HPPE | CAS号 | 1325721-55-8 |
|---|---|---|---|
| 价格 | 纯度 | 98.22% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： HPPE is a specific nonelectrophilic and physiological Bach1 inhibitor via heme-binding sites of Bach1 protein, derepresses Bach1-mediated repression.HPPE induces up-regulation of Hmox1 mRNA is mediated by Bach1 inhibition in vivo.Nuclear export of Bach1 is required for HPPE-mediated Bach1 derepression, HPPE has an additional activity in Nrf2 stabilization besides Bach1 inhibition.Pre- and posttreatment of HPPE is neuroprotective against acute MPTP neurotoxicity.HPPE significantly reduced MPTP-induced increases in TNF-α and Mcp-1 mRNA levels, HPPE significantly increased mRNA levels of Nrf2 compared to MPTP-treated mice that received the vehicle.Bach1 is a known transcriptional repressor of the Nrf2 pathway.Bach1 ablation is cytoprotective, as it suppresses reactive oxygen species (ROS) generation, mitigates excessive inflammation, improves mitochondrial function, and inhibits apoptosis. 物理化学性质： CAS号：1325721-55-8 常用中文名：HPPE 常用英文名：HPPE 分子式：C21H20F3N5O3S 分子量：479.478 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A |
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