SMN2 splicing modulator TEC-1
更新时间：2024-07-17 16:20:32
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| 常用名 | SMN2 splicing modulator TEC-1 | CAS号 | 2407723-70-8 |
|---|---|---|---|
| 价格 | ￥需询单/5mg | 纯度 | 98.0% |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： SMN2 splicing modulator TEC-1 is a novel specific, CNS penetrant small molecule SMN2 splicing modulator, increases the expression level of FL-SMN2 mRNA and decreases the expression level of Δ7 mRNA.TEC-1 showed higher selectively (>60-fold) on galactosylceramidase and huntingtin gene expression compared to previously reported compounds (e.g., SMN-C3) due to off-target effects on cryptic exon inclusion and nonsense-mediated mRNA decay.TEC-1 modulates SMN2 splicing and displays disease-modifying effects in motor neurons derived from SMA patient iPSCs (GM24468).|TEC-1 rescues the phenotype in a murine model of spinal muscular atrophy (SMA). 物理化学性质： CAS号：2407723-70-8 常用中文名：SMN2 splicing modulator TEC-1 常用英文名：SMN2 splicing modulator TEC-1 分子式：C21H23N7O 分子量：389.463 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A |
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