常用名 | JNJ-18038683 free base | CAS号 | 851373-91-6 |
---|---|---|---|
价格 | ¥需询单/25mg ¥需询单/100mg ¥需询单/250mg | 纯度 | 98.0% |
备货期 | 10天 | 库存 | 现货 |
产品详情(用途,包装等)
用途: JNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays; decreases 5-HT (100 nM)-stimulated adenylyl cyclase in rat and human 5-HT7/HEK293 cells with pKb of 8.01 and 7.99, respectively; shows 10-fold selectivity over h5-HT6 receptor, 15-fold selectivity over rat adrenergic α1 receptor, 14- to 25-fold selectivity over the h5-HT2 receptor subtypes, and 20-fold selectivity over h5-HT1B receptor; prolongs rapid eye movement (REM) sleep and decreases REM duration induced by citalopram in vivo. 物理化学性质: CAS号:851373-91-6 常用中文名:JNJ-18038683 free base 常用英文名:JNJ-18038683 free base 分子式:C20H20ClN3 分子量:337.846 密度:1.3±0.1 g/cm3 沸点:547.6±50.0 °C at 760 mmHg 熔点:N/A 闪点:285.0±30.1 °C |